Hello Andy,
- As far I know Client preferance configuration file stored @ C:\Users\<USERNAME>\AppData\Local\EPMOfficeClient\EPMXLClientPreference.XML
- DLL File location is C:\Users\<USERID>\AppData\Local\Programs\SAP BusinessObjects\EPM Add-In
If your IT department needs to re-create user profile you can ask them to copy files in to new profile once new profile created.
Technically you can copy "EPMXLClientPreference.XML" file in to new profile after re-installaing software in client PC.
Please let me know if you need more information.
Regards,
Yogesh